Formation et esprit d'entreprendre chez les étudiants

Cette contribution s'attache à étudier entre esprit d'entreprendre et domaine d'études chez les étudiants français. L'esprit d'entreprendre est le substrat dans lequel peut germer l'intention qui pourra donner lieu à une création d'entreprise. Nous choisissons de l'appréhender à partir d'une grille de lecture dérivée du modèle psychosocial du comportement planifié d'Ajzen, enrichie par des variables reflétant l'implication dans la vie associative et les opinions sur les formations à la création d'entreprise.esprit d'entreprendre ; domaine d'étude ; étudiants français

Humoral Responses against BQ.1.1 Elicited after Breakthrough Infection and SARS-CoV-2 mRNA Vaccination.

The Omicron BQ.1.1 variant is now the major SARS-CoV-2 circulating strain in many countries. Because of the many mutations present in its Spike glycoprotein, this variant is resistant to humoral responses elicited by monovalent mRNA vaccines. With the goal to improve immune responses against Omicron subvariants, bivalent mRNA vaccines have recently been approved in several countries. In this study, we measure the capacity of plasma from vaccinated individuals, before and after a fourth dose of mono- or bivalent mRNA vaccine, to recognize and neutralize the ancestral (D614G) and the BQ.1.1 Spikes. Before and after the fourth dose, we observe a significantly better recognition and neutralization of the ancestral Spike. We also observe that fourth-dose vaccinated individuals who have been recently infected better recognize and neutralize the BQ.1.1 Spike, independently of the mRNA vaccine used, than donors who have never been infected or have an older infection. Our study supports that hybrid immunity, generated by vaccination and a recent infection, induces higher humoral responses than vaccination alone, independently of the mRNA vaccine used

Formation et esprit d'entreprendre chez les étudiants

cahier de recherche n°2009-17 E4Cette contribution s'attache à étudier entre esprit d'entreprendre et domaine d'études chez les étudiants français. L'esprit d'entreprendre est le substrat dans lequel peut germer l'intention qui pourra donner lieu à une création d'entreprise. Nous choisissons de l'appréhender à partir d'une grille de lecture dérivée du modèle psychosocial du comportement planifié d'Ajzen, enrichie par des variables reflétant l'implication dans la vie associative et les opinions sur les formations à la création d'entreprise

Formation et esprit d'entreprendre chez les étudiants

cahier de recherche n°2009-17 E4Cette contribution s'attache à étudier entre esprit d'entreprendre et domaine d'études chez les étudiants français. L'esprit d'entreprendre est le substrat dans lequel peut germer l'intention qui pourra donner lieu à une création d'entreprise. Nous choisissons de l'appréhender à partir d'une grille de lecture dérivée du modèle psychosocial du comportement planifié d'Ajzen, enrichie par des variables reflétant l'implication dans la vie associative et les opinions sur les formations à la création d'entreprise

Modélisation numérique de la fragmentation du sommeil par Réseau de neurones artificiels

International audienc

Expression of S100A8 in leukemic cells predicts poor survival in de novo AML patients.

International audienceCytogenetic stratification remains insufficient for almost half of the acute myeloblastic leukemia (AML) cases, with AML patients requiring subsequent molecular investigation. In our study, we used mass spectrometry (MS)-based proteomic approaches to characterize de novo AML. Fifty-four samples (mononuclear cells from bone marrow or peripheral blood mononuclear cells collected and frozen before treatment) from two independent cohorts of newly diagnosed AML patients were analyzed. We showed that the protein signature of leukemic cells defined two clusters that displayed significant variation for overall and disease-free survival (P=0.001 and 0.0004, respectively). This proteomic classification refines the cytogenetic classes. AML patients with intermediate and unfavorable cytogenetic classifications could be subdivided according to their protein profiles into subgroups with significantly different survival rates. Among the proteins expressed by leukemic cells, we isolated a 10,800-Da marker that retained the highest discriminative value between living and deceased patients. The 10,800-Da marker was identified by MS peptide sequencing as S100A8 (also designated MRP8 or calgranulin A). Western blot analysis confirmed its expression mainly in AML patients with the worst prognosis, arguing for a selective deregulation associated with poor prognosis. These results suggest that the expression of S100A8 in leukemic cells is a predictor of low survival

Spike recognition and neutralization of SARS-CoV-2 Omicron subvariants elicited after the third dose of mRNA vaccine.

Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants have recently emerged, becoming the dominant circulating strains in many countries. These variants contain a large number of mutations in their spike glycoprotein, raising concerns about vaccine efficacy. In this study, we evaluate the ability of plasma from a cohort of individuals that received three doses of mRNA vaccine to recognize and neutralize these Omicron subvariant spikes. We observed that BA.4/5 and BQ.1.1 spikes are markedly less recognized and neutralized compared with the D614G and other Omicron subvariant spikes tested. Also, individuals who have been infected before or after vaccination present better humoral responses than SARS-CoV-2-naive vaccinated individuals, thus indicating that hybrid immunity generates better humoral responses against these subvariants